Research output per year
Research output per year
Personal profile
Research interests
- Natural killer receptors and their ligands: Application for cancer, viral diseases and diabetes
- Patterns of disease (cancer, cardio-vascular, neuro-degenerative) bio-markers in blood.
Roles and Responsibilities
- B.M.Sc. 1980-1982, Hebrew University, Faculty of Medicine.
- B.Sc. 1982-1984, Hebrew university, Faculty of Life Sciences, Department of Computer Sciences.
- M.Sc. 1987-1988, Weizmann Institute of Science, Dept. of Life Sciences. Advisors: Profs. Lea Eisenbach and Michael Feldman. Title: Expression of H-2K gene is correlated with decreased tumorigenicity and metastogenesis in B-16 melanoma cells. Ph.D. 1989-1993, Weizmann Institute of Science, Dept. of Life Sciences, Advisors: Profs. Lea Eisenbach and Michael Feldman, Title: Manipulating malignancy through gene transfer of cytokine genes and MHC class I genes.
Research interests
המעבדה לחקר אימונותרפיה למחלות הסרטן ודיאגנוסטיקה של טיפולים
(רפואת סרטן מותאמת אישית).
המחקר במעבדה הוא מגוון ועוסק בפיתוח נוגדנים כנגד נקודות ביקורת חיסונית של
מערכת החיסון המולדת IMMUNE-CHECKPOINTS , ובפיתוח פרומוטורים
סינטטים לביטוי קולטנים כימרים על תאי T ותאי NK בסביבת הסרטן. בנוסף,
אנו שוקדים על אפיון שיטות תלת-מימדיות EX-VIVO לבדיקת רגישות לתרופות
מוכוונות ותרופות ביולוגיות כנגד סרטן המבוססות על השתלות של תאי גידול
מחולים בעכברי ,(PDX) NSG שיטות מבוססות סיכור חלבונים להארכת חיים
בסרום של תרופות מבוססי חלבונים שהן קיצרות חיים וכן על פיתוח נוגדנים כנגד
הטרודימרים של קולטנים על קרום תא – פנוטיפ המאפיין תאי גידול. כמו כן, אנו
מפתחים ננו-צ'יפים וריפורטרים מלאכותיים לאבחון רגישות ויעילות אימונותרפיה
כנגד גידול (רפואת סרטן מותאמת אישית).
Research interests
The laboratory for cancer immunotherapy and diagnostics (personalized cancer therapy)
The research in the group is quite diverse, incorporating several subjects, including the development of antibodies against immune checkpoints of the innate immune system; exploration of 3D-ex-vivo diagnostic methodologies to evaluate the response to targeted and biological cancer therapies, based on patient-derived xenografts (PDX) grown in NSG mice. We use glycosylation-based methodologies to enhance sera lifespan of short-lived therapeutic proteins; development of antibodies against receptors’ heterodimers whose membrane-expression is abundant in tumor cells; nanochips and artificial reporters to evaluate sensitivity and efficacy of cancer immunotherapy (Personalized Cancer Therapy).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A Novel Approach for Colloidal Lithography: From Dry Particle Assembly to High-Throughput Nanofabrication
Tzadka, S., Ureña Martin, C., Toledo, E., Yassin, A. A. K., Pandey, A., Le Saux, G., Porgador, A. & Schvartzman, M., 10 Apr 2024, In: ACS applied materials & interfaces. 16, 14, p. 17846-17856 11 p.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
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High capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling
Zismanov, S., Shalem, B., Margolin-Miller, Y., Rosin-Grunewald, D., Adar, R., Keren-Naus, A., Amichay, D., Ben-Dor, A., Shemer-Avni, Y., Porgador, A., Shental, N. & Hertz, T., 1 Dec 2024, In: COMMUNICATIONS MEDICINE. 4, 1, 121.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
High capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling
Zismanov, S., Shalem, B., Margolin-Miller, Y., Rosin-Grunewald, D., Adar, R., Keren-Naus, A., Amichay, D., Ben-Dor, A., Shemer-Avni, Y., Porgador, A., Shental, N. & Hertz, T., Dec 2024, In: Communications medicine. 4, 1, 121.Ben-Gurion University of the Negev, Open University of Israel, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
High capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling
Zismanov, S., Shalem, B., Margolin-Miller, Y., Rosin-Grunewald, D., Adar, R., Keren-Naus, A., Amichay, D., Ben-Dor, A., Shemer-Avni, Y., Porgador, A., Shental, N. & Hertz, T., Dec 2024, In: COMMUNICATIONS MEDICINE. 4, 1, 121.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Membrane Fluctuation Model for Understanding the Effect of Receptor Nanoclustering on the Activation of Natural Killer Cells through Biomechanical Feedback
Pandey, A., Nowakowski, P., Ureña Martin, C., Abu Ahmad, M., Edri, A., Toledo, E., Tzadka, S., Walther, J., Le Saux, G., Porgador, A., Smith, A. S. & Schvartzman, M., 8 May 2024, In: Nano Letters. 24, 18, p. 5395-5402 8 p.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review