Personal profile
Research interests
Professor Alon Chen is Director and Scientific Member at the Max Planck Institute of Psychiatry in Munich, Germany. In parallel, he is Head of the Department of Neurobiology at Weizmann Institute of Science, Rehovot, Israel. Alon also serves as the Head of the Max Planck Society - Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics. Alon’s research focuses on the Neurobiology of Stress, particularly the mechanisms by which the brain is regulating the response to stressful challenges and how this response is linked to psychiatric disorders. The collective long-term goal of his research is to elucidate the pathways and mechanisms by which stressors are perceived, processed, and transduced into neuroendocrine and behavioral responses under healthy and pathological conditions. Alon’s lab has made significant discoveries in his field, including fundamental aspects of the organism’s stress response and linking the action of specific stress-related genes, epigenetic mechanisms and brain circuits with anxiety disorders, depression, eating disorders and the metabolic syndrome. Alon and his team use both genetic mouse models and human patients to ultimately create the scientific groundwork for therapeutic interventions to treat stress-related behavioral and physiological disorders.
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Collaborations and top research areas from the last five years
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Disruption of the developmental factor Otp in the adult male forebrain reveals its diverse physiological functions
Tahor, M., Kuperman, Y., Nahum, T., Tsoory, M., Bejar, B., Regev, E., Blechman, J., Biran, J., Chen, A. & Levkowitz, G., Apr 2026, In: Endocrinology. 167, 4, 12 p., bqag029.Research output: Contribution to journal › Article › peer-review
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Intensity and exposure proximity as determinants of differential stress-related health outcomes
Lebow, M., Rotkopf, R., Malik, E., Amitai, M., Weizman, A., Krieger, O., Geyshin, A., Israel, A., Merzon, E., Magen, E., Vinker, S., Nuttman-Shwartz, O. & Chen, A., 6 Mar 2026, In: Molecular Psychiatry. 10 p.Weizmann Institute of Science, Tel Aviv University, Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Mineralocorticoid Receptor in Glutamatergic Neurons Modulates Anxiety Exclusively in Male Mice Via Regulation of the Actin-Bundling Factor Fam107a
Yang, H., Narayan, S., Bordes, J., van Doeselaar, L., De Donno, C., Eder, M., Menegaz, D., Huettl, R. E., Brix, L. M., Mitra, S., Springer, M., Müller, M. B., Chen, A., Deussing, J. M., Lopez, J. P. & Schmidt, M. V., Mar 2026, In: Biological Psychiatry Global Open Science. 6, 2, 12 p., 100651.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell characterization of the adult male hippocampus suggests a prominent, and cell-type specific, role for Nrgn and Sgk1 in response to a social stressor
De Donno, C., Lopez, J. P., Luecken, M. D., Kos, A., Brivio, E., Bordes, J., Yang, H., Deussing, J. M., Schmidt, M. V., Theis, F. J. & Chen, A., 19 Jan 2026, In: Molecular Psychiatry. 31, 3, p. 1823-1836 14 p., PMID 9607835.Research output: Contribution to journal › Article › peer-review
Open Access -
A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
Sen, P., Ortiz, O., Brivio, E., Menegaz, D., Sotillos Elliott, L., Du, Y., Ries, C., Chen, A., Wurst, W., Lopez, J. P., Eder, M. & Deussing, J. M., Jan 2025, In: Molecular Psychiatry. 30, 1, p. 97-110 14 p.Research output: Contribution to journal › Article › peer-review
Open Access