Personal profile
Research interests
Professor Alon Chen is Director and Scientific Member at the Max Planck Institute of Psychiatry in Munich, Germany. In parallel, he is Head of the Department of Neurobiology at Weizmann Institute of Science, Rehovot, Israel. Alon also serves as the Head of the Max Planck Society - Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics. Alon’s research focuses on the Neurobiology of Stress, particularly the mechanisms by which the brain is regulating the response to stressful challenges and how this response is linked to psychiatric disorders. The collective long-term goal of his research is to elucidate the pathways and mechanisms by which stressors are perceived, processed, and transduced into neuroendocrine and behavioral responses under healthy and pathological conditions. Alon’s lab has made significant discoveries in his field, including fundamental aspects of the organism’s stress response and linking the action of specific stress-related genes, epigenetic mechanisms and brain circuits with anxiety disorders, depression, eating disorders and the metabolic syndrome. Alon and his team use both genetic mouse models and human patients to ultimately create the scientific groundwork for therapeutic interventions to treat stress-related behavioral and physiological disorders.
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Collaborations and top research areas from the last five years
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
Sen, P., Ortiz, O., Brivio, E., Menegaz, D., Sotillos Elliott, L., Du, Y., Ries, C., Chen, A., Wurst, W., Lopez, J. P., Eder, M. & Deussing, J. M., Jan 2025, In: Molecular Psychiatry. 30, 1, p. 97-110 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Group Social Dynamics in a Seminatural Setup Reflect the Adaptive Value of Aggression in Male Mice
Anpilov, S., Shemesh, Y., Benjamin, A., Biagini, T., Umanski, D., Zur, Y., Sztainberg, Y., Richter-Levin, A., Forkosh, O. & Chen, A., Jan 2025, In: Biological Psychiatry Global Open Science. 5, 1, 100399.Weizmann Institute of Science, The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
A Discrepancy in the Reports on Life Events Between Parents and Their Depressed Children Is Associated with Lower Responsiveness to SSRI Treatment
Amitai, M., Etedgi, E., Mevorach, T., Kalimi, R., Horesh, N., Oschry-Bernstein, N., Apter, A., Benaroya-Milshtein, N., Fennig, S., Weizman, A. & Chen, A., 1 Nov 2024, In: Journal of Child and Adolescent Psychopharmacology. 34, 9, p. 407-413 7 p.Tel Aviv University, Weizmann Institute of Science, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
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DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory
Marshall, P. R., Davies, J., Zhao, Q., Liau, W. S., Lee, Y., Basic, D., Periyakaruppiah, A., Zajaczkowski, E. L., Leighton, L. J., Madugalle, S. U., Musgrove, M., Kielar, M., Brueckner, A. M., Gong, H., Ren, H., Walsh, A., Kaczmarczyk, L., Jackson, W. S., Chen, A. & Spitale, R. C. & 1 others, , 10 Apr 2024, In: Journal of Neuroscience. 44, 15, 20 p., e0093232024.Research output: Contribution to journal › Article › peer-review
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Neuropsychiatric research in 2023: mechanisms of stress and therapies
Lopez, J. P. & Chen, A., Jan 2024, In: The Lancet Neurology. 23, 1, p. 28-30 3 p.Research output: Contribution to journal › Editorial › peer-review