Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Daniel Alfandari, Sharon Cadury, Mattia I. Morandi, Neta Regev-Rudzki

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)913-928
عدد الصفحات16
دوريةTrends in Parasitology
مستوى الصوت39
رقم الإصدار11
تاريخ مبكر على الإنترنت25 سبتمبر 2023
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - نوفمبر 2023

All Science Journal Classification (ASJC) codes

  • !!Parasitology
  • !!Infectious Diseases

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