To cheat or not to cheat: Tryptophan hydroxylase 2 SNP variants contribute to dishonest behavior

Qiang Shen, Meijun Teo, Eyal Winter, Einav Hart, Soo H. Chew, Richard P. Ebstein

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Although, lying (bear false witness) is explicitly prohibited in the Decalogue and a focus of interest in philosophy and theology, more recently the behavioral and neural mechanisms of deception are gaining increasing attention from diverse fields especially economics, psychology, and neuroscience. Despite the considerable role of heredity in explaining individual differences in deceptive behavior, few studies have investigated which specific genes contribute to the heterogeneity of lying behavior across individuals. Also, little is known concerning which specific neurotransmitter pathways underlie deception. Toward addressing these two key questions, we implemented a neurogenetic strategy and modeled deception by an incentivized die-under-cup task in a laboratory setting. The results of this exploratory study provide provisional evidence that SNP variants across the tryptophan hydroxylase 2 (TPH2) gene, that encodes the rate-limiting enzyme in the biosynthesis of brain serotonin, contribute to individual differences in deceptive behavior.

اللغة الأصليةإنجليزيّة أمريكيّة
رقم المقال82
دوريةFrontiers in Behavioral Neuroscience
مستوى الصوت10
رقم الإصدارMAY
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 3 مايو 2016

All Science Journal Classification (ASJC) codes

  • !!Neuropsychology and Physiological Psychology
  • !!Cognitive Neuroscience
  • !!Behavioral Neuroscience

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