Thymic epithelial cells

Jakub Abramson, Graham Anderson

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity. These properties are collectively required to bias thymocyte development toward production of self-tolerant and functionally competent T cells. The importance of thymic epithelial cells (TECs) is evidenced by clear links between their dysfunction and multiple diseases where autoimmunity and immunodeficiency are major components. Consequently, TECs are an attractive target for cell therapies to restore effective immune system function. The pathways and molecular regulators that control TEC development are becoming clearer, as are their influences on particular stages of T cell development. Here, we review both historical and the most recent advances in our understanding of the cellular and molecular mechanisms controlling TEC development, function, dysfunction, and regeneration.
اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)85-118
عدد الصفحات34
دوريةANNUAL REVIEW OF IMMUNOLOGY
مستوى الصوت35
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 26 أبريل 2017

All Science Journal Classification (ASJC) codes

  • !!Immunology and Allergy
  • !!Immunology

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