Phagocytosis in Drosophila: From molecules and cellular machinery to physiology

C. Melcarne, B. Lemaitre, E. Kurant

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Phagocytosis is an evolutionarily conserved mechanism that plays a key role in both host defence and tissue homeostasis in multicellular organisms. A range of surface receptors expressed on different cell types allow discriminating between self and non-self (or altered) material, thus enabling phagocytosis of pathogens and apoptotic cells. The phagocytosis process can be divided into four main steps: 1) binding of the phagocyte to the target particle, 2) particle internalization and phagosome formation, through remodelling of the plasma membrane, 3) phagosome maturation, and 4) particle destruction in the phagolysosome. In this review, we describe our present knowledge on phagocytosis in the fruit fly Drosophila melanogaster, assessing each of the key steps involved in engulfment of both apoptotic cells and bacteria. We also assess the physiological role of phagocytosis in host defence, development and tissue homeostasis.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)1-12
عدد الصفحات12
دوريةInsect Biochemistry and Molecular Biology
مستوى الصوت109
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - يونيو 2019

All Science Journal Classification (ASJC) codes

  • !!Insect Science
  • !!Molecular Biology
  • !!Biochemistry

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