Paradoxical results of adaptive false discovery rate procedures in neuroimaging studies

Philip T. Reiss, Armin Schwartzman, Feihan Lu, Lei Huang, Erika Proal

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Adaptive false discovery rate (FDR) procedures, which offer greater power than the original FDR procedure of Benjamini and Hochberg, are often applied to statistical maps of the brain. When a large proportion of the null hypotheses are false, as in the case of widespread effects such as cortical thinning throughout much of the brain, adaptive FDR methods can surprisingly reject more null hypotheses than not accounting for multiple testing at all-i.e., using uncorrected p-values. A straightforward mathematical argument is presented to explain why this can occur with the q-value method of Storey and colleagues, and a simulation study shows that it can also occur, to a lesser extent, with a two-stage FDR procedure due to Benjamini and colleagues. We demonstrate the phenomenon with reference to a published data set documenting cortical thinning in attention deficit/hyperactivity disorder. The paper concludes with recommendations for how to proceed when adaptive FDR results of this kind are encountered in practice.

اللغة الأصليةإنجليزيّة أمريكيّة
الصفحات (من إلى)1833-1840
عدد الصفحات8
دوريةNeuroImage
مستوى الصوت63
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - ديسمبر 2012
منشور خارجيًانعم

All Science Journal Classification (ASJC) codes

  • !!Neurology
  • !!Cognitive Neuroscience

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