Mitophagy as a stress response in mammalian cells and in respiring S. Cerevisiae

Hagai Abeliovich, Jörn Dengjel

نتاج البحث: نشر في مجلةعرض مختصرمراجعة النظراء

ملخص

The degradation of malfunctioning or superfluous mitochondria in the lysosome/vacuole is an important housekeeping function in respiring eukaryotic cells. This clearance is thought to occur by a specific form of autophagic degradation called mitophagy, and plays a role in physiological homoeostasis as well as in the progression of late-onset diseases. Although the mechanism of bulk degradation by macroautophagy is relatively well established, the selective autophagic degradation of mitochondria has only recently begun to receive significant attention. In this mini-review, we introduce mitophagy as a form of mitochondrial quality control and proceed to provide specific examples from yeast and mammalian systems. We then discuss the relationship of mitophagy to mitochondrial stress, and provide a broad mechanistic overview of the process with an emphasis on evolutionarily conserved pathways.

اللغة الأصليةإنجليزيّة أمريكيّة
الصفحات (من إلى)541-545
عدد الصفحات5
دوريةBiochemical Society Transactions
مستوى الصوت44
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 15 أبريل 2016

All Science Journal Classification (ASJC) codes

  • !!Biochemistry

بصمة

أدرس بدقة موضوعات البحث “Mitophagy as a stress response in mammalian cells and in respiring S. Cerevisiae'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا