Microarray analysis of oligosaccharide-mediated multivalent carbohydrate–protein interactions and their heterogeneity

Madhuri Gade, Catherine Alex, Shani Leviatan Ben-Arye, João T. Monteiro, Sharon Yehuda, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Carbohydrate–protein interactions (CPIs) are involved in a wide range of biological phenomena. Hence, the characterization and presentation of carbohydrate epitopes that closely mimic the natural environment is one of the long-term goals of glycosciences. Inspired by the multivalency, heterogeneity and nature of carbohydrate ligand-mediated interactions, we constructed a combinatorial library of mannose and galactose homo-and hetero-glycodendrons to study CPIs. Microarray analysis of these glycodendrons with a wide range of biologically important plant and animal lectins revealed that oligosaccharide structures and heterogeneity interact with each other to alter binding preferences.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)1170-1177
عدد الصفحات8
دوريةChemBioChem
مستوى الصوت19
رقم الإصدار11
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 4 يونيو 2018

All Science Journal Classification (ASJC) codes

  • !!Biochemistry
  • !!Molecular Medicine
  • !!Molecular Biology
  • !!Organic Chemistry

بصمة

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