Metalloprotease type III effectors that specifically cleave JNK and NF-κB

Kobi Baruch, Lihi Gur-Arie, Chen Nadler, Simi Koby, Gal Yerushalmi, Yinon Ben-Neriah, Orli Yogev, Eitan Shaulian, Chen Guttman, Raz Zarivach, Ilan Rosenshine

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Two major arms of the inflammatory response are the NF-κB and c-Jun N-terminal kinase (JNK) pathways. Here, we show that enteropathogenic Escherichia coli (EPEC) employs the type III secretion system to target these two signalling arms by injecting host cells with two effector proteins, NleC and NleD. We provide evidence that NleC and NleD are Zn-dependent endopeptidases that specifically clip and inactivate RelA (p65) and JNK, respectively, thus blocking NF-κB and AP-1 activation. We show that NleC and NleD co-operate and complement other EPEC effectors in accomplishing maximal inhibition of IL-8 secretion. This is a remarkable example of a pathogen using multiple effectors to manipulate systematically the host inflammatory response signalling network.

اللغة الأصليةإنجليزيّة أمريكيّة
الصفحات (من إلى)221-231
عدد الصفحات11
دوريةEMBO Journal
مستوى الصوت30
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 5 يناير 2011

All Science Journal Classification (ASJC) codes

  • !!General Immunology and Microbiology
  • !!General Biochemistry, Genetics and Molecular Biology
  • !!Molecular Biology
  • !!General Neuroscience

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