Metabolic remodeling of the human red blood cell membrane measured by quantitative phase microscopy

YongKeun Park, Catherine Best, Thorsten Auth, Nir S. Gov, Samuel Safran, Gabriel Popescu

نتاج البحث: فصل من :كتاب / تقرير / مؤتمرمنشور من مؤتمر

ملخص

We have quantitatively and systemically measured the morphologies and dynamics of fluctuations in human RBC membranes using a full-field laser interferometry technique that accurately measures dynamic membrane fluctuations. We present conclusive evidence that the presence of adenosine 5'-triphosphate (ATP) facilitates nonequilibrium dynamic fluctuations in the RBC membrane and that these fluctuations are highly correlated with specific regions in the biconcave shape of RBCs. Spatial analysis reveals that these nonequilibrium membrane fluctuations are enhanced at the scale of the spectrin mesh size. Our results indicate the presence of dynamic remodeling in the RBC membrane cortex powered by ATP, which results in nonequilibrium membrane fluctuations. (This conference proceeding paper is primary based on our recent publication - please refer to YK Park et al., Proc. Nat. Acad. Sci., 107, 1289 (2010) for details.)

اللغة الأصليةالإنجليزيّة
عنوان منشور المضيفIMAGING, MANIPULATION, AND ANALYSIS OF BIOMOLECULES, CELLS, AND TISSUES IX
المحررونDL Farkas, DV Nicolau, RC Leif
ناشرSPIE
عدد الصفحات9
مستوى الصوت7902
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 22 فبراير 2011
الحدثConference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX - San Francisco, الولايات المتّحدة
المدة: ٢٢ يناير ٢٠١١٢٥ يناير ٢٠١١

سلسلة المنشورات

الاسمProceedings of SPIE
مستوى الصوت7902
رقم المعيار الدولي للدوريات (المطبوع)0277-786X

!!Conference

!!ConferenceConference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
الدولة/الإقليمالولايات المتّحدة
المدينةSan Francisco
المدة٢٢/٠١/١١٢٥/٠١/١١

بصمة

أدرس بدقة موضوعات البحث “Metabolic remodeling of the human red blood cell membrane measured by quantitative phase microscopy'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا