Membrane insertion of—and membrane potential sensing by—semiconductor voltage nanosensors: Feasibility demonstration

Kyoungwon Park, Yung Kuo, Volodymyr Shvadchak, Antonino Ingargiola, Xinghong Dai, Lawrence Hsiung, Wookyeom Kim, Hong Zhou, Peng Zou, Alex J. Levine, Jack Li, Shimon Weiss

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.

اللغة الأصليةالإنجليزيّة
رقم المقالe1601453
دوريةScience Advances
مستوى الصوت4
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - يناير 2018
منشور خارجيًانعم

All Science Journal Classification (ASJC) codes

  • !!General

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