Mammalian Cell Dedifferentiation as a Possible Outcome of Stress

Ofer Shoshani, Dov Zipori

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Differentiation cascades are arranged hierarchically; stem cells positioned at the top of the hierarchy generate committed progenitors that, in turn, proliferate and further differentiate stepwise into mature progeny. This rigid, irreversible structure ensures the phenotypic stability of adult tissues. However, such rigidity may be problematic under conditions of tissue damage when reconstitution is required. Although it may seem unlikely that the restrictions on changes in cell phenotypes would be lifted to enable tissue reconstitution, it is nevertheless possible that mammalian tissues are endowed with sufficient flexibility to enable their adaptation to extreme conditions.
اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)488-493
عدد الصفحات6
دوريةStem cell reviews and reports.
مستوى الصوت7
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 29 يناير 2011
منشور خارجيًانعم

بصمة

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