Large-scale automated histology in the pursuit of Connectomes

David Kleinfeld, Arjun Bharioke, Pablo Blinder, Davi D. Bock, Kevin L. Briggman, Dmitri B. Chklovskii, Winfried Denk, Moritz Helmstaedter, John P. Kaufhold, Wei Chung Allen Lee, Hanno S. Meyer, Kristina D. Micheva, Marcel Oberlaender, Steffen Prohaska, R. Clay Reid, Stephen J. Smith, Shinya Takemura, Philbert S. Tsai, Bert Sakmann

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

How does the brain compute? Answering this question necessitates neuronal connectomes, annotated graphs of all synaptic connections within defined brain areas. Further, understanding the energetics of the brain's computations requires vascular graphs. The assembly of a connectome requires sensitive hardware tools to measure neuronal and neurovascular features in all three dimensions, as well as software and machine learning for data analysis and visualization. We present the state of the art on the reconstruction of circuits and vasculature that link brain anatomy and function. Analysis at the scale of tens of nanometers yields connections between identified neurons, while analysis at the micrometer scale yields probabilistic rules of connection between neurons and exact vascular connectivity.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)16125-16138
عدد الصفحات14
دوريةJournal of Neuroscience
مستوى الصوت31
رقم الإصدار45
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 9 نوفمبر 2011
منشور خارجيًانعم

All Science Journal Classification (ASJC) codes

  • !!General Neuroscience

بصمة

أدرس بدقة موضوعات البحث “Large-scale automated histology in the pursuit of Connectomes'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا