Induction of diffuse axonal brain injury in rats based on rotational acceleration

Dmitry Frank, Israel Melamed, Benjamin F. Gruenbaum, Julia Grinshpun, Ruslan Kuts, Rachel Shvartsur, Abed N. Azab, Mohamad H. Assadi, Max Vinokur, Matthew Boyko

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Traumatic brain injury (TBI) is a major cause of death and disability. Diffuse axonal injury (DAI) is the predominant mechanism of injury in a large percentage of TBI patients requiring hospitalization. DAI involves widespread axonal damage from shaking, rotation or blast injury, leading to rapid axonal stretch injury and secondary axonal changes that are associated with a long-lasting impact on functional recovery. Historically, experimental models of DAI without focal injury have been difficult to design. Here we validate a simple, reproducible and reliable rodent model of DAI that causes widespread white matter damage without skull fractures or contusions.

اللغة الأصليةإنجليزيّة أمريكيّة
رقم المقالe61198
دوريةJournal of Visualized Experiments
مستوى الصوت2020
رقم الإصدار159
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 1 مايو 2020

All Science Journal Classification (ASJC) codes

  • !!General Chemical Engineering
  • !!General Immunology and Microbiology
  • !!General Biochemistry, Genetics and Molecular Biology
  • !!General Neuroscience

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