In vitro testing for hypersensitivity-mediated adverse drug reactions: Challenges and future directions

A. A. Elzagallaai, G. Koren, J. R. Bend, M. J. Rieder

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Drug hypersensitivity reactions (DHRs) are uncommon but potentially fatal adverse events. Their diagnosis and prediction are difficult given their variable presentation and the overlap of symptoms with those of other clinical conditions. Systemic rechallenge is considered the gold standard for the diagnosis of DHRs; however, this may have severe consequences. In vitro tests are currently not sufficiently reliable to provide the basis for clinical decisions. This article summarizes the challenges associated with in vitro testing for DHRs.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)455-460
عدد الصفحات6
دوريةClinical Pharmacology and Therapeutics
مستوى الصوت90
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - سبتمبر 2011
منشور خارجيًانعم

All Science Journal Classification (ASJC) codes

  • !!Pharmacology
  • !!Pharmacology (medical)

بصمة

أدرس بدقة موضوعات البحث “In vitro testing for hypersensitivity-mediated adverse drug reactions: Challenges and future directions'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا