Identification of legionella effectors using bioinformatic approaches

نتاج البحث: فصل من :كتاب / تقرير / مؤتمرفصلمراجعة النظراء

ملخص

Legionella pneumophila the causative agent of Legionnaires' disease, actively manipulates host cell processes to establish a replication niche inside host cells. The establishment of its replication niche requires a functional Icm/Dot type IV secretion system which translocates about 300 effector proteins into host cells during infection. Many of these effectors were first identified as effector candidates by several bioinformatic approaches, and these predicted effectors were later examined experimentally for translocation and a large number of which were validated as effector proteins. Here, I summarized the bioinformatic approaches that were used to identify these effectors.

اللغة الأصليةالإنجليزيّة
عنوان منشور المضيفLegionella
العنوان الفرعي لمنشور المضيفMethods and Protocols
الصفحات595-602
عدد الصفحات8
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 2013

سلسلة المنشورات

الاسمMethods in Molecular Biology
مستوى الصوت954

All Science Journal Classification (ASJC) codes

  • !!Molecular Biology
  • !!Genetics

بصمة

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