Effects of olanzapine on LPS-induced inflammation in rat primary glia cells

Caroline Faour-Nmarne, Abed N. Azab

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

ملخص

Olanzapine (OLZ) is an atypical antipsychotic drug that also has mood-stabilizing effects. The mechanism of action of OLZ is not fully understood. Accumulating data suggest that inflammation plays a role in the pathophysiology of mental disorders and that psychotropic drugs exhibit some anti-inflammatory properties. This study was undertaken to examine the effects of OLZ on LPS-induced inflammation in rat primary glia cells. Glia cells were extracted from newborn rat brains. OLZ (1 or 50 μM) was added to culture medium at 6 or 72 h before addition of LPS for another 18 h, and levels of IL-10, prostaglandin (PG) E2, NO and TNF-α, and expression of cyclo-oxygensase (COX)-2 and inducible NO synthase (iNOS) were determined. Treatment with 50 μM OLZ (but not 1 μM) significantly decreased LPS-induced secretion of IL-10, PGE2 and TNF-α. In contrast, 50 μM OLZ significantly increased NO levels. OLZ did not alter the expression of COX-2 or iNOS in LPS-treated cells. These results suggest that OLZ differently affects the secretion of inflammatory mediators. Most of the significant effects of OLZ were obtained when 50 μM was used, which is a high and probably therapeutically irrelevant concentration. Therefore, under the conditions used in the present study OLZ seemed to lack a potent anti-inflammatory effect.

اللغة الأصليةإنجليزيّة أمريكيّة
الصفحات (من إلى)40-50
عدد الصفحات11
دوريةInnate Immunity
مستوى الصوت22
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 1 يناير 2016

All Science Journal Classification (ASJC) codes

  • !!Microbiology
  • !!Immunology
  • !!Molecular Biology
  • !!Cell Biology
  • !!Infectious Diseases

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