Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment

Tehila Cohen, Noam Shomron

نتاج البحث: نشر في مجلةمقالة مرجعيةمراجعة النظراء

ملخص

Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.

اللغة الأصليةالإنجليزيّة
رقم المقال12908
دوريةINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
مستوى الصوت24
رقم الإصدار16
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - أغسطس 2023

All Science Journal Classification (ASJC) codes

  • !!Catalysis
  • !!Molecular Biology
  • !!Spectroscopy
  • !!Computer Science Applications
  • !!Physical and Theoretical Chemistry
  • !!Organic Chemistry
  • !!Inorganic Chemistry

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